Modern ImmunosuppressivesHenk-Jan Schuurman, Gilles Feutren, Jean-François Bach Springer Science & Business Media, 2001 - 218 páginas Expanding from the classic use of immunosuppressants in transplantation and rejection, this current overview highlights their new roles in clinical medicine. Immunosuppressants are at the forefront of new treatment modalities. Individual chapters focus on their use not only in prevention or treatment of transplant rejection, but also on their use in immune-complex and autoimmune diseases, including rheumatoid arthritis; on combination therapies to achieve synergy in immunosuppression; on new drugs, low molecular weight chemicals, the use of antibodies and gene therapy; on immunological tolerance to prevent or inhibit transplant rejection; and how data derived from transplant studies can be applied to other avenues of immunosuppression. Clinicians and researchers will appreciate the scope of the work and the presentation of new approaches in the rapidly developing field of immunosuppression. |
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Índice
| 11 | |
| 29 | |
| 43 | |
| 77 | |
| 97 | |
| 99 | |
Targeting the IL2 receptor with antibodies or chimeric toxins | 115 |
New avenues in immunosuppression | 123 |
Emerging therapeutic strategies for the prevention and treatment of chronic allograft rejection | 125 |
Tolerance induction | 149 |
Gene therapy approaches to immunosuppression | 169 |
Perspectives | 181 |
A rigorous approach to the diagnosis of synergy among combination therapies of immunosuppressive agents | 183 |
Lessons for transplantation of cyclosporine experience in the treatment of autoimmune diseases | 201 |
Subject index | 215 |
Outras edições - Ver tudo
Modern Immunosuppressives Henk-Jan Schuurman,Gilles Feutren,Jean-François Bach Pré-visualização limitada - 2001 |
Palavras e frases frequentes
activity acute rejection acute rejection episodes agents allograft allograft recipients allograft survival antigen azathioprine blood bone marrow calcineurin cardiac allograft chimeric chronic rejection Clin combination concentrations correlation cyclosporine cytokine donor dose drug effect efficacy endothelial estrogen expression function gene therapy graft survival growth factor Häyry heart transplant human immune Immunol immunosuppressive incidence of acute induced infection inhibition inhibitor interactions interleukin-2 Kahan BD kidney transplantation levels ligand liver transplantation long-term lung transplantation lymphocytes mAbs mg/kg/d mice MoAbs models molecules monitoring monoclonal antibody multicenter murine mycophenolate mofetil mycophenolic acid Neoral nephrotoxicity ng/ml novo OKT3 organ transplantation pharmacokinetic post-transplantation proliferation protein RAPA rapamycin receptor regimen renal transplant renal transplant recipients rescue therapy response Sandimmune serum side-effects sirolimus smooth muscle cells steroids Study Group synergism T-cell tacrolimus tacrolimus FK506 target therapeutic tion tissue tolerance toxicity transplant patients Transplant Proc treatment trough vascular versus vitro vivo
Passagens conhecidas
Página 112 - O'Garra, A., Bigler, M., Rouleau, M., Antonenko, S., de Vries, JE, et al. (1997) A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.
Página 95 - A blinded, randomized clinical trial of mycophenolate mofetil for the prevention of acute rejection in cadaveric renal transplantation. Transplantation.
Página 112 - Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor p after antigen-specific triggering.
Página 72 - Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J Antibiot (Tokyo) 1975; 28:721-726.
Página 120 - Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.
Página 122 - Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. Protein Eng.
Página 146 - Lindner V, Reidy MA. Proliferation of smooth muscle cells after vascular injury is inhibited by an antibody against basic fibroblast growth factor. Proc Natl Acad Sci USA 1991; 88:3739-3743.
Página 179 - Vaux DL. Transgenic expression of CD95 ligand on islet beta cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts. Proc Natl Acad Sci USA 1997: 94:3943-3947.
Informação bibliográfica
| Título | Modern Immunosuppressives Milestones in drug therapy |
| Editores | Henk-Jan Schuurman, Gilles Feutren, Jean-François Bach |
| Edição | ilustrada |
| Editora | Springer Science & Business Media, 2001 |
| ISBN | 3764359811, 9783764359812 |
| Número de páginas | 218 páginas |
| Exportar citação | BiBTeX EndNote RefMan |