considerable pain over the region of the heart, and a loud and pure systolic bruit was now heard. In the evening, Dr. Cockle examined the heart, and confirmed the diagnosis of the systolic bruit.

Fifteenth Day. The general symptoms were the same; the cough continued. I noticed, for the first time, a little fulness of the abdomen. Drs. Fuller, Cockle, and Meredith saw the animal this day, and listened to the systolic murmur, which was extremely well marked, and could be heard generally in the cardiac region. In the course of the day, the tension of the abdomen increased rapidly, showing that there was some effusion; and, in the evening, I drew off by puncture six ounces of a thin darkish fluid.

Sixteenth Day. The general symptoms were the same. The systolic bruit was very loud and harsh. There was a little exudation from the wound. The urine was strongly acid. Drs. Hawksley, F. Webb, and Cockle examined the heart this day, and confirmed the diagnosis of a systolic bruit.

Seventeenth Day. On visiting the animal this morning, I found a return of the pain in the limbs, together with considerable exhaustion. When his limbs were touched, he grew angry, but could not stand nor move his head without great pain and difficulty. When food and drink were brought, and placed conveniently for his mouth, he raised himself slowly, so as to eat and drink, which he did with great avidity. During the whole of the day, he could not move his limbs, and cried when they were touched. The systolic bruit was still well marked.

Eighteenth Day. Early on this morning, the tenderness of the limbs entirely diappeared. He ran about

freely, and took his food and drink as though in perfect health. At ten a.m. Dr. Todd saw him, and confirmed the fact of the systolic bruit. There was, however, some little tenderness over the region of the heart when the stethoscope was applied. A few hours later, he suddenly relapsed into his previous condition, becoming violently enraged whenever his limbs were touched. He vomited a little once, and was freely purged two or three times, the excreta having a neutral reaction; but he passed a large quantity of strongly acid urine. After this, he seemed greatly relieved.

Nineteenth Day. He was more lively, and took his food heartily. He was frequently purged, the excreta having a yeast-like appearance and acid reaction. The urine had a strong acid reaction. The systolic bruit was loud and prolonged. Mr. Haynes Walton and Dr. W. R. Rogers saw him this afternoon, and heard the bruit. The body of the animal on this and several days past had a peculiar sour smell, which scented the whole of a room very quickly.

Twentieth Day. The animal continued the same. There was free purgation; the excreta still had an acid reaction.

Twenty-first Day. He was better. The purging had ceased altogether. He ate and drank well, and ran about without any difficulty; but he gave evidence of pain when the stethoscope was firmly placed on the chest. The systolic bruit was very loud, and was heard over a large surface. Drs. Camps, Henry, and Seaton saw him this day, and confirmed the existence of the systolic murmur.

From this time, recovery rapidly took place; and, day by day, the systolic murmur became more feeble,