Nature, Volume 429Sir Norman Lockyer Macmillan Journals Limited, 2004 |
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Página 87
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
Página 89
... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells resulted in no significant change in p53 messenger RNA levels . However , using pulse - chase analysis , transfection of ...
... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells resulted in no significant change in p53 messenger RNA levels . However , using pulse - chase analysis , transfection of ...
Página 91
... COP1 - Luc Fold - increase of COP1 mRNA 16 14- 2 d 10 WB : COP1 ∞ Vector p53 p53R175H WB : COP1 WB : p53 WB : p53 WB : actin WB : actin WB : p21 0 Vector p53 p53R175H Untreated + IR Figure 5 COP1 is a p53 - inducible gene . a ...
... COP1 - Luc Fold - increase of COP1 mRNA 16 14- 2 d 10 WB : COP1 ∞ Vector p53 p53R175H WB : COP1 WB : p53 WB : p53 WB : actin WB : actin WB : p21 0 Vector p53 p53R175H Untreated + IR Figure 5 COP1 is a p53 - inducible gene . a ...
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