Nature, Volume 429Sir Norman Lockyer Macmillan Journals Limited, 2004 |
No interior do livro
Resultados 1-3 de 8
Página 87
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
... COP1 serves as an E3 ubiquitin ligase for p53 in vitro and in vivo , and inhibits p53 - dependent transcription and apoptosis . Depletion of COP1 by short interfering RNA ( siRNA ) stabilizes p53 and arrests cells in the G1 phase of the ...
Página 88
... COP1 or COP1ARING was extracted , and p53 mRNA levels were assessed by real - time PCR and normalized to ẞ - actin mRNA . d , COP1 increases p53 turnover . HEK293T cells were transfected with or without COP1 , and the half - life of ...
... COP1 or COP1ARING was extracted , and p53 mRNA levels were assessed by real - time PCR and normalized to ẞ - actin mRNA . d , COP1 increases p53 turnover . HEK293T cells were transfected with or without COP1 , and the half - life of ...
Página 89
... COP1 was able to decrease the steady - state levels of endogenous p53 in U2 - OS cells ( Fig . 2b ) . To gain ... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells ...
... COP1 was able to decrease the steady - state levels of endogenous p53 in U2 - OS cells ( Fig . 2b ) . To gain ... COP1 inhibited p53 gene transcription ( Fig . 2c ) . Transfection of Flag - COP1 or Flag - COP1ARING in U2 - OS cells ...
Outras edições - Ver tudo
Palavras e frases frequentes
actin activity addition analysis animal applications areas associated authors B-cells biology candidates cells Centre climate close complex containing contribute COP1 core corresponding culture Department detection determine disease drug effects et al example experience expression factor field Figure function funding further gene genetic genome growth human increase indicate individual Institute interactions interests International involved laboratory leading levels limited materials measured mechanism Methods molecular Nature observed obtained organizer performed plants pollen population position potential predicted present production protein publishing record region regulation response role says Science scientific scientists selection sequence shown signal single species structure successful suggest Supplementary surface temperature transcription University western blot