Nature, Volume 429Sir Norman Lockyer Macmillan Journals Limited, 2004 |
No interior do livro
Resultados 1-3 de 9
Página 197
... Rap1 GAP elutes with an apparent molecular mass of ~ 100 kDa . The size of the dimer interface is approximately 2,400 Å2 and is formed mainly by hydrophobic residues . Each monomer consists of two domains , which we call the ...
... Rap1 GAP elutes with an apparent molecular mass of ~ 100 kDa . The size of the dimer interface is approximately 2,400 Å2 and is formed mainly by hydrophobic residues . Each monomer consists of two domains , which we call the ...
Página 199
... Rap1 and Rap1GAP ( N290A ) , which turns out to be 3 μM ( Fig . 3b ) . The affinity between Rap1 - GTP and wild - type Rap1 GAP has been determined to be 14 μM ( ref . 12 ) . Thus the affinity of the mutant is even higher than that of ...
... Rap1 and Rap1GAP ( N290A ) , which turns out to be 3 μM ( Fig . 3b ) . The affinity between Rap1 - GTP and wild - type Rap1 GAP has been determined to be 14 μM ( ref . 12 ) . Thus the affinity of the mutant is even higher than that of ...
Página 200
... Rap1 or RheB . Because a construct encompassing the catalytic domain of tuberin has no GAP activity on RheB or Rap1 ( data not shown ) under standard conditions , we assume that hamartin , which binds to tuberin and is required for its ...
... Rap1 or RheB . Because a construct encompassing the catalytic domain of tuberin has no GAP activity on RheB or Rap1 ( data not shown ) under standard conditions , we assume that hamartin , which binds to tuberin and is required for its ...
Outras edições - Ver tudo
Palavras e frases frequentes
acid activity analysis antibodies apoptosis applications AQPO assays asteroids B-cells bioinformatics Biol biotechnology cancer candidates caspase cell biology cellular Centre climate clinical cloning COP1 core culture Department detection disease domain drug e-mail effects experience expression field function funding galectin-2 gastrulation gene genetic genome global granule cells growth human increase indicate Institute interactions Japan laboratory ligand magnetic mammalian MDMA mechanism membrane mice molecular biology molecules mouse mutant nature publishing group Naturejobs neurons Neuroscience nuclear observed ocean ORF2 oxygen photons Phys pollen pollen tubes position postdoctoral potential predicted production protein proteomics publishing group npg Rap1 rats receptor region response retrotransposition retrotransposon ribozyme RN-tre says Science scientific scientists sequence signal siRNA species stem cells structure Supplementary Fig surface target temperature tissue transcription transfected transgenic University wild-type