TABLE OF CONTENTS.

History of melanosis.

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Pages 1-3.

Primary and secondary melanosis.-Its most frequent seat as a primary disease.

-The appearances presented by primary melanosis.—-Character of melanosis

in the skin

.. Page 3.

Degeneration of cutaneous warts.-Characters of melanosis in the eye.-

Observations of Mr. Wardrop on its presence in the conjunctiva.—Müller, in

the lower jaw.-Rarity of melanosis as a primary disease in bone.-Mr.

Stanley

Page 4.

Mode in which melanosis develops itself in the cellular membrane.-This

tissue very frequently affected secondarily.-Mr. Moore's case of primary

melanotic cancer of the rectum.-The forms under which melanosis presents

itself as a secondary deposit

Page 5.

The melanotic matter deposited in streaks on the surface of parts; in a liquid

state. Rarely encysted.-Cruveilhier's illustration of the encysted form

of melanosis.-The melanotic masses are not vascular; their consistence;

their colour in various localities

Page 6.

Mr. Coote's observations on the tissues in which melanosis has not been found.

-Author's observations.—Infrequency of the liver's being affected, refuted.—

Ascertained weight of certain livers affected by melanosis.-The character

assumed by the deposit in this organ

Page 7.

The gall bladder has not been found affected by melanosis. Of the peculiarity

of the deposit in the folds of the peritoneum.-M. Lebert's case.-M.

Cruveilhier's case of deposit in the interior of the intestinal tube Page 8.

Peculiarity of the deposit of melanosis in serous membranes.-Breschet's,

Sir A. Halliday's, and Mr. Coote's observations on its deposit in the uterus

and ovaries.—In the testicle, by Mr. Curling, M. Cruveilhier, and Mr.

Stanley

Page 9.

Melanosis in the lungs, Bayle and Carswell on certain characteristics of.-

Lawrence and Andral on its appearances in the heart

Page 10.

Cruveilhier's illustration of melanotic deposit in the heart.-Dr. Carswell, Sir

A. Halliday, and Dr. Hooper, on its condition in the brain . . Page 11.

Dr. Wardrop on fungus melanodes of the brain.-Dr. Alderson on melanosis of

the cerebellum.

Page 12.

Page 13.

Lobstein on infiltration of the optic thalamus by black matter.-Melanosis in

the nervous system generally.-Velpeau on its presence in the mammary

glands

Mode in which the vascular system is affected by melanosis.-On its presence

in the thyroid gland, as observed by Alibert and Laennec.-In lymphatic

glands. In the muscular tissue. In the fibrous tissue.-Breschet's, Dr. Norris',

Sir A. Halliday's, Cruveilhier's, and the author's illustrations of this. Page 14.

Andral on the presence of melanosis in the bones.-Sir A. Halliday's case. Page 15.

Messrs. Cullen and Carswell on the same subject.-Absorption of the osseous

texture by melanotic deposit.-Lobstein on infiltration of bone.-Mr. Prescott

Hewett's observations

Page 17.

Mr. Coote on deposit of melanotic tubercles in the diploe.-Mr. Stanley's

opinion of the character of melanotic deposit in bone.-Table of the relative

frequency of the affection of the internal organs and the tissues generally by

melanosis

Page 17.

Page 18.

Page 19.

Pages 20-22.

Pages 22-24.

Table in regard to age and sex.—Table in regard to primary seat.
Frequency of melanosis in connexion with congenital marks.-Early age at
which it may be developed.-Mr. Wardrop's, Mr. Hancock's, and Mr. Paget's
cases.- —On the hereditary transmission of melanosis

Details of a case of melanosis observed by the author

Details of a second case observed by the author.

Peculiarities of the progress of the melanotic tubercle.-Series of cases of

melanosis showing, more particularly, the duration of the disease, the duration

of life after operative interference, rate of recurrence in the cicatrix, and the

appearance of secondary deposits

Pages 25-34.

Page 34.

Page 35.

Table showing the total duration from first appearance to termination

Table showing the duration of life after operation.

Table showing the cases and the period in which recurrence took place at

the original seat, and the period also when secondary deposits manifested

themselves externally

Page 36.

The nature of melanosis-Its microscopic appearance-Distinctions between
melanosis and non-malignant melanosis of the skin

Suggestions as to treatment

Pages 37-38.

Page 38.

DESCRIPTION OF THE PLATES.

PLATE I.

Fig. 1 represents the appearance of the primary disease in the case of H. W. J. (p. 20). The warty character of the growth is pourtrayed with the slate-coloured melanotic changes irregularly dividing its otherwise pink aspect.

Fig. 2. Melanotic subcutaneous tubercles, situated on the front of the leg in various stages of growth.

Fig. 3. The same, from over the head of the tibia, more advanced, and assuming the condition of flattened tubercles, and partially softening.

PLATE II.

The primary disease in the case of P. C. (p. 22).

PLATE III.

An internal view of the calvarium. The dura mater has been stripped off. The bone is seen stained with melanotic patches. Some of these may be observed to stain across the diploe.

PLATE IV.

A view of the posterior aspect of the heart, showing the deposit of melanosis beneath the pericardium, on the fleshy substance of the ventricle.