PREFACE.

These observations on Melanosis appeared in the early part of last year in the Midland Quarterly Journal of the Medical Sciences; they form the first portion of a series of observations on the history, pathology, and treatment of cancerous diseases generally, on which I am now occupied.

The next division of the subject will be comprised under the designation of Encephaloid Cancer, and will be shortly published.

The distinctness of Melanosis and the peculiar interest belonging to many of its features warrant, in my judgment, its appearance in the present form.

To those gentlemen who have so freely communicated to me the cases of this disease which have occurred in their practice my acknowledgments are especially due, and to none more than to my distinguished friends Mr. Paget and Mr. Holmes Coote.

On the completion of this work an Appendix will be added to bring up the present state of our knowledge regarding Melanosis.