Nature, Volume 450Sir Norman Lockyer Macmillan Journals Limited, 2007 |
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... molecules align in a crystal . Even the smallest compound may have hundreds of thousands of possible arrangements of its molecules in a solid crystal . The structure depends on the energies of the atoms both within and between the ...
... molecules align in a crystal . Even the smallest compound may have hundreds of thousands of possible arrangements of its molecules in a solid crystal . The structure depends on the energies of the atoms both within and between the ...
Página 1001
... molecules that bind with drug - like potencies to ' hotspots ' on the contact surfaces involved in protein - protein interactions . Remarkably , these small molecules bind deeper within the contact surface of the target protein , and ...
... molecules that bind with drug - like potencies to ' hotspots ' on the contact surfaces involved in protein - protein interactions . Remarkably , these small molecules bind deeper within the contact surface of the target protein , and ...
Página 1002
... molecules , SP4206 ( Fig . 2 ; Table 1 ) , has a dissociation constant in the mid - nanomolar range ( K = 60 nM ) and disrupts the interaction between IL - 2 and the a - chain of the IL - 2 receptor ( IL - 2Ra ) 29-31 . These molecules ...
... molecules , SP4206 ( Fig . 2 ; Table 1 ) , has a dissociation constant in the mid - nanomolar range ( K = 60 nM ) and disrupts the interaction between IL - 2 and the a - chain of the IL - 2 receptor ( IL - 2Ra ) 29-31 . These molecules ...
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