Nature, Volume 434Sir Norman Lockyer Macmillan Journals Limited, 2005 |
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Página 105
... Clb5 - Cdk1 complex15 , but the broad significance of this interaction for CDK substrate targeting remains unclear . We therefore analysed the effects of hydrophobic patch mutations on the phosphorylation of Clb5 - specific substrates ...
... Clb5 - Cdk1 complex15 , but the broad significance of this interaction for CDK substrate targeting remains unclear . We therefore analysed the effects of hydrophobic patch mutations on the phosphorylation of Clb5 - specific substrates ...
Página 106
... CLB5 was replaced with that of CLB2 at the CLB5 locus . As shown previously , the clb5 :: CLB2 strain provides an excellent system in which to compare the intrinsic specificity of the two cyclins in the absence of normal differences in ...
... CLB5 was replaced with that of CLB2 at the CLB5 locus . As shown previously , the clb5 :: CLB2 strain provides an excellent system in which to compare the intrinsic specificity of the two cyclins in the absence of normal differences in ...
Página 107
... Clb5-3HA Clb2 Clb2-3HA Clb2 b Clb5-3HA H1K C Clb2-3HA H1K Fin1 - TAP Fin1 - TAP Fin1 - TAP d Sld2 - TAP Sld2 - TAP e Slk19-13Myc Sik19-13Myc Wild type clb5 :: CLB2-3HA Wild type clb5 :: CLB2-3HA Wild type clb5 :: CLB2 fin1 :: fin1 ...
... Clb5-3HA Clb2 Clb2-3HA Clb2 b Clb5-3HA H1K C Clb2-3HA H1K Fin1 - TAP Fin1 - TAP Fin1 - TAP d Sld2 - TAP Sld2 - TAP e Slk19-13Myc Sik19-13Myc Wild type clb5 :: CLB2-3HA Wild type clb5 :: CLB2-3HA Wild type clb5 :: CLB2 fin1 :: fin1 ...
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acid activity analysis antibody antigen apoptotic apoptotic cell applications areas assays binding biodiversity Biol biology cancer candidate CD8+ T cells Cell Biology centre Clb5 cluster complex cross-presentation cyclins dendritic detected drug electron emission encoded error experience expression function gap junctions GCRT gene genetic genome helpless CD8+ human HutP hydrogenosomes images indicated infection Institute interactions Izumo kinase laboratory levels ligand males measured mechanism mice mitochondrial molecular molecules monocytes mRNA mutant nanoparticles Nature nature publishing group Naturejobs observed ovalis peptide PGC-la PH domain PH-c phosphorylation Phys programme protein pyruvate quantum computing qubits radiolarites receptor region samples SCAN1 Science scientists sequence shown signalling siRNA SIRT1 sonoluminescence specific sperm structure substrates Supplementary Fig Supplementary Information Supplementary Table surface target TDP1 temperature transcription TRPC3 University wild-type XRCC1