Nature, Volume 434Sir Norman Lockyer Macmillan Journals Limited, 2005 |
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Página 110
... XRCC1 - mutant EM9 Chinese hamster ovary cells harbouring empty expression vector ( EM9 - V ) or human XRCC1 cDNA ( EM9 - XH ) , or in human A549 lung carcinoma cells or a derivative of A549 cells with stable PNK knockdown ( C - ter3 ) ...
... XRCC1 - mutant EM9 Chinese hamster ovary cells harbouring empty expression vector ( EM9 - V ) or human XRCC1 cDNA ( EM9 - XH ) , or in human A549 lung carcinoma cells or a derivative of A549 cells with stable PNK knockdown ( C - ter3 ) ...
Página 111
... XRCC1 Lig3a CD + 32p 18 25 -OH P- TDP 18 - Y 18 - OH 18 - P n CD + Lig3a 1 2 3 4 5 6 7 89 1 150 608 43 32p TDP1-150 n + PNK TDP150-608 CD C IP d Input TDP IgG 150 100 TDP1 75 Lig3a 50 XRCC1 PNK 43 IgG - / - + / + - / - + / + - / - + / + ...
... XRCC1 Lig3a CD + 32p 18 25 -OH P- TDP 18 - Y 18 - OH 18 - P n CD + Lig3a 1 2 3 4 5 6 7 89 1 150 608 43 32p TDP1-150 n + PNK TDP150-608 CD C IP d Input TDP IgG 150 100 TDP1 75 Lig3a 50 XRCC1 PNK 43 IgG - / - + / + - / - + / + - / - + / + ...
Página 915
... XRCC1 . The means and standard deviation of three to nine experiments are shown . We found an induction of y - H2AX foci in both V - C8 and V - C8 + B2 ( BRCA2 complimented ) cells treated with NU1025 ( statistically significant in t ...
... XRCC1 . The means and standard deviation of three to nine experiments are shown . We found an induction of y - H2AX foci in both V - C8 and V - C8 + B2 ( BRCA2 complimented ) cells treated with NU1025 ( statistically significant in t ...
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acid activity analysis antibody antigen apoptotic apoptotic cell applications areas assays binding biodiversity Biol biology cancer candidate CD8+ T cells Cell Biology centre Clb5 cluster complex cross-presentation cyclins dendritic detected drug electron emission encoded error experience expression function gap junctions GCRT gene genetic genome helpless CD8+ human HutP hydrogenosomes images indicated infection Institute interactions Izumo kinase laboratory levels ligand males measured mechanism mice mitochondrial molecular molecules monocytes mRNA mutant nanoparticles Nature nature publishing group Naturejobs observed ovalis peptide PGC-la PH domain PH-c phosphorylation Phys programme protein pyruvate quantum computing qubits radiolarites receptor region samples SCAN1 Science scientists sequence shown signalling siRNA SIRT1 sonoluminescence specific sperm structure substrates Supplementary Fig Supplementary Information Supplementary Table surface target TDP1 temperature transcription TRPC3 University wild-type XRCC1