Nature, Volume 456Sir Norman Lockyer Macmillan Journals Limited, 2008 |
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... CRTC2 and FOXO1 during fasting . RNAi - mediated depletion of hepatic CRTC2 reduced the gluconeogenic profile , which includes Ad - G6Pase - luc activity , gluconeogenic gene expres- sion , and circulating blood glucose concentrations ...
... CRTC2 and FOXO1 during fasting . RNAi - mediated depletion of hepatic CRTC2 reduced the gluconeogenic profile , which includes Ad - G6Pase - luc activity , gluconeogenic gene expres- sion , and circulating blood glucose concentrations ...
Página 271
... CRTC2 induction ( Fig . 2c , bottom ) . Because they both have intrinsic HAT activity , CBP and p300 might be expected to modulate CRTC2 activity in part through acet- ylation . Indeed , overexpression of CBP increased the amounts of ...
... CRTC2 induction ( Fig . 2c , bottom ) . Because they both have intrinsic HAT activity , CBP and p300 might be expected to modulate CRTC2 activity in part through acet- ylation . Indeed , overexpression of CBP increased the amounts of ...
Página 272
... CRTC2 after prolonged exposure of wild - type cells to glucagon , how- ever , CRTC2 protein amounts remained elevated in Sirt1 ̄ / ̄ cells . We observed similar differences in hepatic CRTC2 protein amounts between wild - type and Sirt1 ...
... CRTC2 after prolonged exposure of wild - type cells to glucagon , how- ever , CRTC2 protein amounts remained elevated in Sirt1 ̄ / ̄ cells . We observed similar differences in hepatic CRTC2 protein amounts between wild - type and Sirt1 ...
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