Nature, Volume 456Sir Norman Lockyer Macmillan Journals Limited, 2008 |
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Página 350
... PPAR - y has been intensively studied as a drug target because of its link to insulin sensitization . Previous structural studies have focused on isolated DNA or ligand - binding segments , with no demonstration of how multiple domains ...
... PPAR - y has been intensively studied as a drug target because of its link to insulin sensitization . Previous structural studies have focused on isolated DNA or ligand - binding segments , with no demonstration of how multiple domains ...
Página 351
... PPAR - y protein has its LBD and DBD closely positioned . In contrast , the RXR - α LBD and DBD are far apart from each other , with the space between them filled by the PPAR - y LBD . The PPAR - Y LBD has been the most exploitable drug ...
... PPAR - y protein has its LBD and DBD closely positioned . In contrast , the RXR - α LBD and DBD are far apart from each other , with the space between them filled by the PPAR - y LBD . The PPAR - Y LBD has been the most exploitable drug ...
Página 352
... PPAR LBD H11 s3- H2b H11 H10 H2a H10 H12 H7 s3 Leu 237 $ 4 Asn 335 Phe 347 ... y LBD and the DBD CTE region of RXR - a . The DNA dependence of this ... PPAR - y LBD . A feature unique to the LBD of PPARS is their ẞ - strand elements S1 ...
... PPAR LBD H11 s3- H2b H11 H10 H2a H10 H12 H7 s3 Leu 237 $ 4 Asn 335 Phe 347 ... y LBD and the DBD CTE region of RXR - a . The DNA dependence of this ... PPAR - y LBD . A feature unique to the LBD of PPARS is their ẞ - strand elements S1 ...
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