Nature, Volume 456Sir Norman Lockyer Macmillan Journals Limited, 2008 |
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... complex is associated with argonaute , the RNase H - like PIWI domain of which catalyses guide - strand - mediated ... complex formation . The bound guide strand is anchored at both of its ends , with the solvent - exposed Watson - Crick ...
... complex is associated with argonaute , the RNase H - like PIWI domain of which catalyses guide - strand - mediated ... complex formation . The bound guide strand is anchored at both of its ends , with the solvent - exposed Watson - Crick ...
Página 921
... complex . An arginine , inserted between guide - strand bases 10 and 11 in the binary complex , locking it in an inactive conformation , is released on ternary complex formation . The nucleic - acid - binding channel between the PAZ ...
... complex . An arginine , inserted between guide - strand bases 10 and 11 in the binary complex , locking it in an inactive conformation , is released on ternary complex formation . The nucleic - acid - binding channel between the PAZ ...
Página 922
... complex . Å The 2-8 seed segment formed by the guide DNA - target RNA duplex in the ternary Ago complex superpositions quite well with an A - form helix ( Fig . 2d , left panel ) and less well with its B - form helical counterpart ( Fig ...
... complex . Å The 2-8 seed segment formed by the guide DNA - target RNA duplex in the ternary Ago complex superpositions quite well with an A - form helix ( Fig . 2d , left panel ) and less well with its B - form helical counterpart ( Fig ...
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