Nature, Volume 456Sir Norman Lockyer Macmillan Journals Limited, 2008 |
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Página 354
... region 170- 193 from exchange , the portion of PPAR - y that inserts into the minor groove of the 5 ' DRI extension . The amino - acid region 434-442 in helix 10 and region 333-340 also showed slower exchange compared with the PPAR - y ...
... region 170- 193 from exchange , the portion of PPAR - y that inserts into the minor groove of the 5 ' DRI extension . The amino - acid region 434-442 in helix 10 and region 333-340 also showed slower exchange compared with the PPAR - y ...
Página 404
... Region B associates with DI - III to obstruct the active site in the extended substrate - like orientation . Intrinsic disorder in the free state enables calpastatin to adapt structurally on binding to the substrate - binding cleft of ...
... Region B associates with DI - III to obstruct the active site in the extended substrate - like orientation . Intrinsic disorder in the free state enables calpastatin to adapt structurally on binding to the substrate - binding cleft of ...
Página 405
... region B corresponding to Lys 176 - Leu 188 , which in our complex targets mainly DI , also interacts with calpain . At this CaCl2 level the protease core is not aligned for catalysis and , therefore , the N terminus of Occluded active ...
... region B corresponding to Lys 176 - Leu 188 , which in our complex targets mainly DI , also interacts with calpain . At this CaCl2 level the protease core is not aligned for catalysis and , therefore , the N terminus of Occluded active ...
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