NatureSir Norman Lockyer Macmillan Journals Limited, 2007 |
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Página 105
... LSD1 ( refs 3 , 4 ) interacts with p53 to repress p53 - mediated transcriptional activation and to inhibit the role of p53 in promoting apoptosis . We find that , in vitro , LSD1 removes both monomethylation ( K370me1 ) and ...
... LSD1 ( refs 3 , 4 ) interacts with p53 to repress p53 - mediated transcriptional activation and to inhibit the role of p53 in promoting apoptosis . We find that , in vitro , LSD1 removes both monomethylation ( K370me1 ) and ...
Página 106
... LSD1 was decreased by siRNA treat- ment ( Fig . 2c ) . These results indicate that LSD1 represses the activity of p53 in part through decreasing the binding of p53 to DNA . After DNA damage , p53 activates the expression of genes ...
... LSD1 was decreased by siRNA treat- ment ( Fig . 2c ) . These results indicate that LSD1 represses the activity of p53 in part through decreasing the binding of p53 to DNA . After DNA damage , p53 activates the expression of genes ...
Página 107
... LSD1 . To assess whether the demethylation activity of LSD1 is required for its repression of the transcriptional activity of p53 , we ectopically expressed LSDI and LSD1 ( K661A ) , a demethylation - defective mutant , together with ...
... LSD1 . To assess whether the demethylation activity of LSD1 is required for its repression of the transcriptional activity of p53 , we ectopically expressed LSDI and LSD1 ( K661A ) , a demethylation - defective mutant , together with ...
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Immunology | 35 |
Preclinical research studies | 113 |
An essential resource for immunology researchers | 374 |
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