NatureSir Norman Lockyer Macmillan Journals Limited, 2007 |
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Página 167
... target - based drug design ( see ' Drug discovery : from the genome to the clinic ' , overleaf ) . This approach exploits both chemical ( for example , protein structure- activity data and drug binding - site features ) and genomic ...
... target - based drug design ( see ' Drug discovery : from the genome to the clinic ' , overleaf ) . This approach exploits both chemical ( for example , protein structure- activity data and drug binding - site features ) and genomic ...
Página 168
... Target selection Cloning and construct design Protein production Molecular- target assay development Preclinical toxicity analysis Access to chemical Fragment Chemical library libraries subsets Molecular - target subset screening ...
... Target selection Cloning and construct design Protein production Molecular- target assay development Preclinical toxicity analysis Access to chemical Fragment Chemical library libraries subsets Molecular - target subset screening ...
Página 921
... target seed sequences for miR - 196 and miR - 448 as opposed to JFH1 ( Fig . 3a ) . As J6CF is non - infectious in vitro , we employed an infection - competent J6CF / JFH1 chimaeric virus that carried the ' mutant ' miR - 448 and miR ...
... target seed sequences for miR - 196 and miR - 448 as opposed to JFH1 ( Fig . 3a ) . As J6CF is non - infectious in vitro , we employed an infection - competent J6CF / JFH1 chimaeric virus that carried the ' mutant ' miR - 448 and miR ...
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Immunology | 35 |
Preclinical research studies | 113 |
An essential resource for immunology researchers | 374 |
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