Nature, Volume 428Sir Norman Lockyer Macmillan Journals Limited, 2004 |
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Página 190
... Cks1 are the substrate - targeting subunits of the SCFSkp2 - Cks1 ( Skp1 / Cul1 / F - box protein ) ubiquitin ligase complex that regulates entry into S phase by inducing the degradation of the cyclin - dependent kinase inhibitors p21 ...
... Cks1 are the substrate - targeting subunits of the SCFSkp2 - Cks1 ( Skp1 / Cul1 / F - box protein ) ubiquitin ligase complex that regulates entry into S phase by inducing the degradation of the cyclin - dependent kinase inhibitors p21 ...
Página 191
... Cks1 , a much less pronounced upregulation of p21 and p27 as compared with control cells ( Fig . 2a ) , and an increase in the half - life of both Skp2 and Cks1 ( Fig . 2b ) . We also silenced Cdh1 expression in T98G cells exiting the ...
... Cks1 , a much less pronounced upregulation of p21 and p27 as compared with control cells ( Fig . 2a ) , and an increase in the half - life of both Skp2 and Cks1 ( Fig . 2b ) . We also silenced Cdh1 expression in T98G cells exiting the ...
Página 192
... Cks1 Cdc20 Cdc20 + Cks1 Cks1 Cdh1 IB : Cks1 IB : Cdh1 / Cdc20 ( anti - HA ) Cks1 Cdh1 / Cdc20 ( anti - HA ) Lysate IP : anti - HA Figure 3 Requirements for APC / CCdh1 - mediated degradation of Skp2 and Cks1 . a - f , Immunoblots . a ...
... Cks1 Cdc20 Cdc20 + Cks1 Cks1 Cdh1 IB : Cks1 IB : Cdh1 / Cdc20 ( anti - HA ) Cks1 Cdh1 / Cdc20 ( anti - HA ) Lysate IP : anti - HA Figure 3 Requirements for APC / CCdh1 - mediated degradation of Skp2 and Cks1 . a - f , Immunoblots . a ...
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