Nature, Volume 448Sir Norman Lockyer Macmillan Journals Limited, 2007 |
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Página 207
... supercoils . In vivo experi- ments in the budding yeast verified the resulting prediction that positive supercoils would accumulate during transcription and replication as a consequence of camptothecin poisoning of topoi- somerase I ...
... supercoils . In vivo experi- ments in the budding yeast verified the resulting prediction that positive supercoils would accumulate during transcription and replication as a consequence of camptothecin poisoning of topoi- somerase I ...
Página 209
... supercoils are generated in their wake . Diverging transcription units bisect a plasmid into twin domains of positive and negative supercoils . If , in the presence of drug ( left ) , positive supercoils are removed more slowly than ...
... supercoils are generated in their wake . Diverging transcription units bisect a plasmid into twin domains of positive and negative supercoils . If , in the presence of drug ( left ) , positive supercoils are removed more slowly than ...
Página 210
... supercoils would accumulate during cellular processes that induce DNA supercoiling , such as transcrip- tion24,25 . Thus , we treat G1 - phase - arrested top14 TOP2 yeast cells ( Fig . 3a ) expressing low levels of plasmid - encoded ...
... supercoils would accumulate during cellular processes that induce DNA supercoiling , such as transcrip- tion24,25 . Thus , we treat G1 - phase - arrested top14 TOP2 yeast cells ( Fig . 3a ) expressing low levels of plasmid - encoded ...
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