Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 11
... Gompertz function is typically used. Although other functions have been proposed (Wilson, 1994), the Gompertz function is generally the most adequate for these calculations, particularly when using small populations as is common in ...
... Gompertz function is typically used. Although other functions have been proposed (Wilson, 1994), the Gompertz function is generally the most adequate for these calculations, particularly when using small populations as is common in ...
Página 19
... Gompertz mortality model. J Gerontol A Biol Sci Med Sci 51, B183–B194. Font, E., Desfilis, E., Perez-Canellas, M.M., and Garcia-Verdugo, J.M. (2001). Neurogenesis and neuronal regeneration in the adult reptilian brain. Brain Behav Evol ...
... Gompertz mortality model. J Gerontol A Biol Sci Med Sci 51, B183–B194. Font, E., Desfilis, E., Perez-Canellas, M.M., and Garcia-Verdugo, J.M. (2001). Neurogenesis and neuronal regeneration in the adult reptilian brain. Brain Behav Evol ...
Página 20
... –6598. Wilson, D.L. (1994). The analysis of survival (mortality) data: Fitting Gompertz, Weibull, and logistic functions. Mech Ageing Dev 74, 15–33. Animals, and in particular rats and mice, have long been 20 Joa ̃o Pedro de Magalha ̃es.
... –6598. Wilson, D.L. (1994). The analysis of survival (mortality) data: Fitting Gompertz, Weibull, and logistic functions. Mech Ageing Dev 74, 15–33. Animals, and in particular rats and mice, have long been 20 Joa ̃o Pedro de Magalha ̃es.
Página 21
... Gompertz equation, though originally devised in another context, provides a good guide to the estimation of relative mouse costs, too; because the risk of mortality increases exponentially with age, so does the cost of producing a live ...
... Gompertz equation, though originally devised in another context, provides a good guide to the estimation of relative mouse costs, too; because the risk of mortality increases exponentially with age, so does the cost of producing a live ...
Página 45
... Gompertz and Weibull functions in different. Mathematical models of systems failure are critically important for understanding the mechanisms of aging because aging of organisms is associated with increased risk of failure of its ...
... Gompertz and Weibull functions in different. Mathematical models of systems failure are critically important for understanding the mechanisms of aging because aging of organisms is associated with increased risk of failure of its ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish