Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 10
... aging in model organisms may include numerous anatomical, physiological, and biochemical age-related changes (Finch, 1990). Consequently, one way to determine rate of aging is to study the pace of age-related changes and/or the onset of age ...
... aging in model organisms may include numerous anatomical, physiological, and biochemical age-related changes (Finch, 1990). Consequently, one way to determine rate of aging is to study the pace of age-related changes and/or the onset of age ...
Página 33
... aging is the dramatic increase in morbidity and mortality due to infections. Aging is also the most significant risk factor for developing cancer. Both phenomena are related to the age-associated decline in immune function, particularly ...
... aging is the dramatic increase in morbidity and mortality due to infections. Aging is also the most significant risk factor for developing cancer. Both phenomena are related to the age-associated decline in immune function, particularly ...
Página 40
... aging. ALZHEIMER'S DISEASE AND ATHEROSCLEROSIS There is some evidence that chronic activation of T cells, leading to increased proliferation and telomere shortening, may be involved in other age-related diseases as well. The etiology of ...
... aging. ALZHEIMER'S DISEASE AND ATHEROSCLEROSIS There is some evidence that chronic activation of T cells, leading to increased proliferation and telomere shortening, may be involved in other age-related diseases as well. The etiology of ...
Página 97
... age-related policy issues, visit the U.S. Senate Special Committee on Aging Web site. Visitors can view video or read testimonies from hearings, which the committee uses to guide recommendations for new legislation to the United States ...
... age-related policy issues, visit the U.S. Senate Special Committee on Aging Web site. Visitors can view video or read testimonies from hearings, which the committee uses to guide recommendations for new legislation to the United States ...
Página 111
... age, in other words, biomarkers of age. It is important to recognize that the gene expression changes observed from this type of design don't confer any information about genes that determine longevity or rate of ... Aging-Related Research.
... age, in other words, biomarkers of age. It is important to recognize that the gene expression changes observed from this type of design don't confer any information about genes that determine longevity or rate of ... Aging-Related Research.
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish