Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 36
... decline in the ability to perform antigen-specific lysis of target cells pulsed with HIV peptides, a change that is accompanied by reduced expression of perforin (Dagarag et al., 2004; Yang et al., 2005). Moreover, one of the key ...
... decline in the ability to perform antigen-specific lysis of target cells pulsed with HIV peptides, a change that is accompanied by reduced expression of perforin (Dagarag et al., 2004; Yang et al., 2005). Moreover, one of the key ...
Página 54
... DECLINE IN SYSTEMS' REDUNDANCY WITH AGE Many age changes in living organisms can be explained by cumulative effects of cell loss over time. For example, the very common phenomenon of hair graying with age is caused by depletion of hair ...
... DECLINE IN SYSTEMS' REDUNDANCY WITH AGE Many age changes in living organisms can be explained by cumulative effects of cell loss over time. For example, the very common phenomenon of hair graying with age is caused by depletion of hair ...
Página 126
... decline of certain behavioral capacities; and (5) their large brains allow detailed in vivo imaging (Walker and Cork, 1999; Bussiere et al., 2002; Voytko and Tinkler, 2004). Aging canine Cerebral amyloid deposition was first noted in a ...
... decline of certain behavioral capacities; and (5) their large brains allow detailed in vivo imaging (Walker and Cork, 1999; Bussiere et al., 2002; Voytko and Tinkler, 2004). Aging canine Cerebral amyloid deposition was first noted in a ...
Página 135
... decline localizes, in part, to the hippocampal formation, a brain circuit made up of separate but interconnected ... decline with advancing aging (Zelinski and Burnight, 1997). Luckily for us, age-related cognitive decline is not diffuse ...
... decline localizes, in part, to the hippocampal formation, a brain circuit made up of separate but interconnected ... decline with advancing aging (Zelinski and Burnight, 1997). Luckily for us, age-related cognitive decline is not diffuse ...
Página 138
... decline (i.e., related to Alzheimer's disease) versus a ''normal pattern'' of decline. Specifically, since the effect of normal aging on the brain is, by definition, a stochastic process, the variance of signal intensity among an older ...
... decline (i.e., related to Alzheimer's disease) versus a ''normal pattern'' of decline. Specifically, since the effect of normal aging on the brain is, by definition, a stochastic process, the variance of signal intensity among an older ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish