Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 13
... factors determine rate of aging in primates and makes New World monkeys a valuable source of models of aging. Moving further away from humans, tarsiers (family: Tarsiidae; genus: Tarsius) also appear to be short-lived with short ...
... factors determine rate of aging in primates and makes New World monkeys a valuable source of models of aging. Moving further away from humans, tarsiers (family: Tarsiidae; genus: Tarsius) also appear to be short-lived with short ...
Página 33
... factors, such as smoking—is the greatest risk factor for the development of cancer. One of the major contributory factors to the age-related changes in Handbook of Models for Human Aging infection and cancer is the waning protective ...
... factors, such as smoking—is the greatest risk factor for the development of cancer. One of the major contributory factors to the age-related changes in Handbook of Models for Human Aging infection and cancer is the waning protective ...
Página 145
... factors or protective factors for diseases and functional impairments, and to quantify their impact on disease (or functional impairment) occurrence by measures such as the relative risk, the risk difference or more recently developed ...
... factors or protective factors for diseases and functional impairments, and to quantify their impact on disease (or functional impairment) occurrence by measures such as the relative risk, the risk difference or more recently developed ...
Página 146
... factors or protective factors at a given point of time. This approach is often less challenging in terms of costs and logistics, particularly in comparison with cohort studies, but is more prone to certain biases, which may be ...
... factors or protective factors at a given point of time. This approach is often less challenging in terms of costs and logistics, particularly in comparison with cohort studies, but is more prone to certain biases, which may be ...
Página 147
... factors potentially associated with lower odds of surviving up to old age needs to be interpreted with particular caution, however. For example, the decrease in prevalence of major cardiovascular risk factors at higher ages, such as ...
... factors potentially associated with lower odds of surviving up to old age needs to be interpreted with particular caution, however. For example, the decrease in prevalence of major cardiovascular risk factors at higher ages, such as ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish