Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 11
... function is typically used. Although other functions have been proposed (Wilson, 1994), the Gompertz function is generally the most adequate for these calculations, particularly when using small populations as is common in studies of ...
... function is typically used. Although other functions have been proposed (Wilson, 1994), the Gompertz function is generally the most adequate for these calculations, particularly when using small populations as is common in studies of ...
Página 33
... function, particularly within the T cell compartment, the part of the immune system that patrols the body for cells that appear foreign, which would indicate they are infected or cancerous. Development of long-term cell culture ...
... function, particularly within the T cell compartment, the part of the immune system that patrols the body for cells that appear foreign, which would indicate they are infected or cancerous. Development of long-term cell culture ...
Página 34
... function in entirely different ways. B cells produce soluble proteins known as antibodies, which can neutralize or otherwise inhibit the activity of foreign pathogens. Thus, B cells are responsible for the so-called humoral immune ...
... function in entirely different ways. B cells produce soluble proteins known as antibodies, which can neutralize or otherwise inhibit the activity of foreign pathogens. Thus, B cells are responsible for the so-called humoral immune ...
Página 36
... function in senescent cultures (Pawelec et al., 1986). As CD8þ T cells undergo increasing numbers of cell divisions in long-term culture, they show a variety of alterations that would be predicted to dramatically affect in vivo immune ...
... function in senescent cultures (Pawelec et al., 1986). As CD8þ T cells undergo increasing numbers of cell divisions in long-term culture, they show a variety of alterations that would be predicted to dramatically affect in vivo immune ...
Página 39
... function of other immune cells. Senescent CD8þ T cells have also been associated with suppressive effects in organ transplant patients. Donor-specific CD8þCD28À T cells are detectable in the peripheral blood of those patients with ...
... function of other immune cells. Senescent CD8þ T cells have also been associated with suppressive effects in organ transplant patients. Donor-specific CD8þCD28À T cells are detectable in the peripheral blood of those patients with ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish