Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 28
... gene expression survey which focused on comparisons of control, food-restricted, and slow-aging dwarf mutants at early or middle adult ages is expected to be more fruitful than one which instead compiled lists of genes whose expression ...
... gene expression survey which focused on comparisons of control, food-restricted, and slow-aging dwarf mutants at early or middle adult ages is expected to be more fruitful than one which instead compiled lists of genes whose expression ...
Página 35
... expression of the alpha chain of the IL-2 receptor in response to specific antigen, despite the inability to enter ... gene expression of this key T cell signaling molecule. Whereas characterization of senescence-associated changes using ...
... expression of the alpha chain of the IL-2 receptor in response to specific antigen, despite the inability to enter ... gene expression of this key T cell signaling molecule. Whereas characterization of senescence-associated changes using ...
Página 99
... genes and gene products. The rate of aging will certainly depend on gene identity, gene polymorphism, the rate of translation, developmental regulation of translation, the residence time of gene products in the organism, and post ...
... genes and gene products. The rate of aging will certainly depend on gene identity, gene polymorphism, the rate of translation, developmental regulation of translation, the residence time of gene products in the organism, and post ...
Página 109
... genome is sequenced, along with genomes from dozens of other organisms; genome-wide protein–protein interaction maps have been generated for most of the major model systems; simultaneous gene expression profiling for tens of thousands of ...
... genome is sequenced, along with genomes from dozens of other organisms; genome-wide protein–protein interaction maps have been generated for most of the major model systems; simultaneous gene expression profiling for tens of thousands of ...
Página 110
... gene expression levels for thousands of genes simultaneously. This is accomplished by obtaining RNA from a cell, tissue, or organism, and quantifying the amount of mRNA present for each gene being assayed. One of the most basic ...
... gene expression levels for thousands of genes simultaneously. This is accomplished by obtaining RNA from a cell, tissue, or organism, and quantifying the amount of mRNA present for each gene being assayed. One of the most basic ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish