Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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... individuals surpassing 8 years. Sacher's laboratory published about a dozen papers comparing house and white-footed mice ... individual of a given species has not been easy. For instance, the maximum lifespan of rhesus macaques, capuchin ...
... individuals surpassing 8 years. Sacher's laboratory published about a dozen papers comparing house and white-footed mice ... individual of a given species has not been easy. For instance, the maximum lifespan of rhesus macaques, capuchin ...
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... individual in the four-way cross population is a full sib of each other individual; each is genetically unique, but shares 50% of its alleles with any other mouse in the test population. Populations of this kind have genetic ...
... individual in the four-way cross population is a full sib of each other individual; each is genetically unique, but shares 50% of its alleles with any other mouse in the test population. Populations of this kind have genetic ...
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... individual donor. In such cases it will be necessary to test multiple pools of individuals from each age or ... individual protocol will need to balance the practicality, and cost, of testing individual subjects against the loss of power ...
... individual donor. In such cases it will be necessary to test multiple pools of individuals from each age or ... individual protocol will need to balance the practicality, and cost, of testing individual subjects against the loss of power ...
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... individual system described in preceding sections. Figure 5.9 presents the age kinetics of failure rate in heterogeneous population where redundancy is distributed by the Poisson law (a special case of binomial distribution) with ...
... individual system described in preceding sections. Figure 5.9 presents the age kinetics of failure rate in heterogeneous population where redundancy is distributed by the Poisson law (a special case of binomial distribution) with ...
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... individual's judgment in order to do what is in that person's best interests. Still, the first duty of respect is to honor the autonomy of persons. Research with older subjects can test the richness of this principle as an analytical ...
... individual's judgment in order to do what is in that person's best interests. Still, the first duty of respect is to honor the autonomy of persons. Research with older subjects can test the richness of this principle as an analytical ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish