Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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... lifespan extension literature, as CR is to date the only intervention that reliably increases lifespan in mammals (Weindruch et al., 1982; Yu et al., 1985; Walford et al., 1992). At the same time the Walford group was engaged in its ...
... lifespan extension literature, as CR is to date the only intervention that reliably increases lifespan in mammals (Weindruch et al., 1982; Yu et al., 1985; Walford et al., 1992). At the same time the Walford group was engaged in its ...
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... lifespan. Other estimates of aging have been used such as adult mortality rates, average longevity, and adult lifespan. Adult mortality rates and average longevity did not correlate well with the MRDT or with physiological aging ...
... lifespan. Other estimates of aging have been used such as adult mortality rates, average longevity, and adult lifespan. Adult mortality rates and average longevity did not correlate well with the MRDT or with physiological aging ...
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... lifespan, a rate of aging, from what we know, comparable to that of humans, and are considerably bigger than us. The hippopotamus (Hippopotamus amphibius), which has a maximum lifespan of 61 years and an MRDT of 7 years, rhinoceros ...
... lifespan, a rate of aging, from what we know, comparable to that of humans, and are considerably bigger than us. The hippopotamus (Hippopotamus amphibius), which has a maximum lifespan of 61 years and an MRDT of 7 years, rhinoceros ...
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... lifespan in mice (Bartke et al., 2001; Bluher et al., 2003; Holzenberger et al., 2003; Miller, 2001; Miskin and Masos, 1997; Tatar et al., 2003). Here the increases in maximal lifespan provide presumptive evidence that the aging process ...
... lifespan in mice (Bartke et al., 2001; Bluher et al., 2003; Holzenberger et al., 2003; Miller, 2001; Miskin and Masos, 1997; Tatar et al., 2003). Here the increases in maximal lifespan provide presumptive evidence that the aging process ...
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... lifespan of about 50%. Long- and short-lived breeds of dogs, single gene mutants in mice, diet-induced lifespan expansion—each produces changes of 50% or less in the pace of aging, functional decline, and change in mortality risks ...
... lifespan of about 50%. Long- and short-lived breeds of dogs, single gene mutants in mice, diet-induced lifespan expansion—each produces changes of 50% or less in the pace of aging, functional decline, and change in mortality risks ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish