Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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... longer lived species like dogs, monkeys, and humans. The best solution would be to develop a set of measures that could be used to assess the life-lengthening effects of an intervention in significantly less than the full lifespan of ...
... longer lived species like dogs, monkeys, and humans. The best solution would be to develop a set of measures that could be used to assess the life-lengthening effects of an intervention in significantly less than the full lifespan of ...
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... live more than twice as long as either wild-caught or laboratory house mice—more than 3.75 years on average with the longest-lived individuals surpassing 8 years. Sacher's laboratory published about a dozen papers comparing house and ...
... live more than twice as long as either wild-caught or laboratory house mice—more than 3.75 years on average with the longest-lived individuals surpassing 8 years. Sacher's laboratory published about a dozen papers comparing house and ...
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... long-lived mouse stock. Exp. Gerontol. 40, 303–314. Hart, R.W., Neumann, D.A., and Robertson, R.T. (Eds.) (1995). Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. Washington ...
... long-lived mouse stock. Exp. Gerontol. 40, 303–314. Hart, R.W., Neumann, D.A., and Robertson, R.T. (Eds.) (1995). Dietary Restriction: Implications for the Design and Interpretation of Toxicity and Carcinogenicity Studies. Washington ...
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... long-lived when compared to their closest relatives. The brown lemur can live 37 years, which is impressive considering it reaches sexual maturity at about age 2. It was also reported that a hybrid between a brown and a black lemur lived ...
... long-lived when compared to their closest relatives. The brown lemur can live 37 years, which is impressive considering it reaches sexual maturity at about age 2. It was also reported that a hybrid between a brown and a black lemur lived ...
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... Longest-lived marmoset White-faced capuchin Cebus capucinus 54.8 4–8 2 Example of a long-lived Platyrrhini Tarsiidae Tarsiers Tarsius genus 15 1–2 0.1–0.2 Generally short-lived Strepsirrhini Brown lemur Eulemur fulvus 37 2 2 Longest-lived ...
... Longest-lived marmoset White-faced capuchin Cebus capucinus 54.8 4–8 2 Example of a long-lived Platyrrhini Tarsiidae Tarsiers Tarsius genus 15 1–2 0.1–0.2 Generally short-lived Strepsirrhini Brown lemur Eulemur fulvus 37 2 2 Longest-lived ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish