Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 12
... mechanisms of aging are conserved across distant species, and it is possible that they are not (de Magalhaes, 2004). Since there is still no definitive answer to this debate, my position in this work is that species biologically and ...
... mechanisms of aging are conserved across distant species, and it is possible that they are not (de Magalhaes, 2004). Since there is still no definitive answer to this debate, my position in this work is that species biologically and ...
Página 13
... mechanisms (Promislow, 1994). In other words, the evolution of aging rates and DNA repair may have been related to body size and thus independent from one another. Therefore, body size is a factor that comparative studies of aging must ...
... mechanisms (Promislow, 1994). In other words, the evolution of aging rates and DNA repair may have been related to body size and thus independent from one another. Therefore, body size is a factor that comparative studies of aging must ...
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... mechanisms could potentially allow us to employ them in human medicine. The best example is certainly the bowhead ... mechanisms that are absent from humans, such as anticancer mechanisms. Similar examples include elephants (Elephas ...
... mechanisms could potentially allow us to employ them in human medicine. The best example is certainly the bowhead ... mechanisms that are absent from humans, such as anticancer mechanisms. Similar examples include elephants (Elephas ...
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... mechanisms to protect against reactive oxygen species formation and damage (Lutz et al., 2003). Likewise, neurogenesis may be predominant in reptiles (Font et al., 2001). Since other turtles may feature negligible senescence and oocyte ...
... mechanisms to protect against reactive oxygen species formation and damage (Lutz et al., 2003). Likewise, neurogenesis may be predominant in reptiles (Font et al., 2001). Since other turtles may feature negligible senescence and oocyte ...
Página 28
... mechanisms. An alternate design, already in fashion for studies of invertebrate aging, involves comparisons of young or middle-aged subjects that are known to be aging at different rates. There are now at least two diets that slow aging ...
... mechanisms. An alternate design, already in fashion for studies of invertebrate aging, involves comparisons of young or middle-aged subjects that are known to be aging at different rates. There are now at least two diets that slow aging ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish