Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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... normal ovarian epithelial cells, this complex actually binds to the hTERT promoter region (Misiti et al., 2000). It has been known for some time that T cells can bind to estrogen via specific estrogen receptors. Thus, we tested whether ...
... normal ovarian epithelial cells, this complex actually binds to the hTERT promoter region (Misiti et al., 2000). It has been known for some time that T cells can bind to estrogen via specific estrogen receptors. Thus, we tested whether ...
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... normal on those cells that were registered as being CD28þ (Effros et al., 1994a). There was an intriguing ... normal, epithelial cells to proliferate in culture and also to form tumors in SCID mice, suggestive of a potential role in age ...
... normal on those cells that were registered as being CD28þ (Effros et al., 1994a). There was an intriguing ... normal, epithelial cells to proliferate in culture and also to form tumors in SCID mice, suggestive of a potential role in age ...
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... normal elderly humans: The T cell equivalent to ''benign monoclonal gammopathy.'' Journal of Experimental Medicine 179,609–618. Roggia, C., Gao, Y., Cenci, S., Weitzmann, M.N., Toraldo, G., Isaia, G. et al. (2001). Up-regulation of TNF ...
... normal elderly humans: The T cell equivalent to ''benign monoclonal gammopathy.'' Journal of Experimental Medicine 179,609–618. Roggia, C., Gao, Y., Cenci, S., Weitzmann, M.N., Toraldo, G., Isaia, G. et al. (2001). Up-regulation of TNF ...
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... normal (H) or heavy (D) hydrogen isotopes. When two pools of proteins are labeled with the normal or heavy isotope-containing ICAT reagent, their relative abundance can be determined by quantitative MS analysis of the ratio of normal to ...
... normal (H) or heavy (D) hydrogen isotopes. When two pools of proteins are labeled with the normal or heavy isotope-containing ICAT reagent, their relative abundance can be determined by quantitative MS analysis of the ratio of normal to ...
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P. Michael Conn. NORMAL AGING OR DISEASE? A key issue for AD model development is whether AD is a pathological process or whether it is part of the normal sequence of aging. It is not as easy to decide this as it might seem. Sporadic AD ...
P. Michael Conn. NORMAL AGING OR DISEASE? A key issue for AD model development is whether AD is a pathological process or whether it is part of the normal sequence of aging. It is not as easy to decide this as it might seem. Sporadic AD ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish