Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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... span predictions from the Gompertz mortality model. J Gerontol A Biol Sci Med Sci 51, B183–B194. Font, E., Desfilis, E., Perez-Canellas, M.M., and Garcia-Verdugo, J.M. (2001). Neurogenesis and neuronal regeneration in the adult ...
... span predictions from the Gompertz mortality model. J Gerontol A Biol Sci Med Sci 51, B183–B194. Font, E., Desfilis, E., Perez-Canellas, M.M., and Garcia-Verdugo, J.M. (2001). Neurogenesis and neuronal regeneration in the adult ...
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... span and cellular resistance to stress. Free Radical Biology & Medicine 26, 495–500. Kinney B.A., Meliska C.J., Steger R.W., and Bartke A. (2001). Evidence that Ames dwarf mice age differently from their normal siblings in behavioral ...
... span and cellular resistance to stress. Free Radical Biology & Medicine 26, 495–500. Kinney B.A., Meliska C.J., Steger R.W., and Bartke A. (2001). Evidence that Ames dwarf mice age differently from their normal siblings in behavioral ...
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... Span Genetics Using the Kinetic Analysis. Thesis, Moscow, Russia: Moscow State University. Gavrilov, L.A. (1984). Does a limit of the life span really exist? Biofizika 29, 908–911. Gavrilov, L.A., and Gavrilova, N.S. (1979) ...
... Span Genetics Using the Kinetic Analysis. Thesis, Moscow, Russia: Moscow State University. Gavrilov, L.A. (1984). Does a limit of the life span really exist? Biofizika 29, 908–911. Gavrilov, L.A., and Gavrilova, N.S. (1979) ...
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... span can be used as a guideline. For example, an old age-point could be defined as 50% or 75% of the median longevity. It must be kept in mind, however, that the older an animal is at the latest age-point, the more likely that age ...
... span can be used as a guideline. For example, an old age-point could be defined as 50% or 75% of the median longevity. It must be kept in mind, however, that the older an animal is at the latest age-point, the more likely that age ...
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... Span. in. Simple. Eukaryotes. Simple eukaryotic models, such as yeast, worms, and flies, have had a significant impact on aging-related research, largely due to their short life span and genetic tractability (see Chapters 17–25). Nearly all ...
... Span. in. Simple. Eukaryotes. Simple eukaryotic models, such as yeast, worms, and flies, have had a significant impact on aging-related research, largely due to their short life span and genetic tractability (see Chapters 17–25). Nearly all ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish