Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 16
... telomerase and a continuous molting which may be partly responsible for its continuous growth and negligible rate of aging (Klapper et al., 1998). Moreover, species with negligible senescence are important in understanding how the ...
... telomerase and a continuous molting which may be partly responsible for its continuous growth and negligible rate of aging (Klapper et al., 1998). Moreover, species with negligible senescence are important in understanding how the ...
Página 19
... Telomerase activity in 'immortal' fish. FEBS Lett 434, 409–412. Lutz, P.L., Prentice, H.M., and Milton, S.L. (2003). Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation? Exp Gerontol 38, 797 ...
... Telomerase activity in 'immortal' fish. FEBS Lett 434, 409–412. Lutz, P.L., Prentice, H.M., and Milton, S.L. (2003). Is turtle longevity linked to enhanced mechanisms for surviving brain anoxia and reoxygenation? Exp Gerontol 38, 797 ...
Página 36
... telomerase, which uses its RNA template to synthesize the telomere sequence. Human and mouse cells show fundamental differences with respect to telomere size and telomerase activity. Because of the significantly longer telomeres in ...
... telomerase, which uses its RNA template to synthesize the telomere sequence. Human and mouse cells show fundamental differences with respect to telomere size and telomerase activity. Because of the significantly longer telomeres in ...
Página 37
... telomerase activity. Finally, the distinct contribution of CD28 to telomerase activation was evident in experiments using Cyclosporin, a TCR signaling inhibitor. Cyclosporin was not able to inhibit telomerase in T cells activated by a ...
... telomerase activity. Finally, the distinct contribution of CD28 to telomerase activation was evident in experiments using Cyclosporin, a TCR signaling inhibitor. Cyclosporin was not able to inhibit telomerase in T cells activated by a ...
Página 41
... telomerase induction during T cell activation. Experimental Cell Research 228, 58–64. Borthwick, N.J., Bofill, M., and Gombert, W.M. (1994). Lymphocyte activation in HIV-1 infection II. Functional defects of CD28-T cells. AIDS 8,431–441 ...
... telomerase induction during T cell activation. Experimental Cell Research 228, 58–64. Borthwick, N.J., Bofill, M., and Gombert, W.M. (1994). Lymphocyte activation in HIV-1 infection II. Functional defects of CD28-T cells. AIDS 8,431–441 ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish