Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 36
... telomere shortening with cell division. Once the telomere reaches a certain critical length, the DNA damage signaling pathway is activated, with the concomitant up-regulation of cell cycle inhibitors. The process of replicative ...
... telomere shortening with cell division. Once the telomere reaches a certain critical length, the DNA damage signaling pathway is activated, with the concomitant up-regulation of cell cycle inhibitors. The process of replicative ...
Página 37
... telomerase activity. Finally, the distinct contribution of CD28 to telomerase ... telomere shortening in the replicative senescence ''program'' in T cells ... length stabilization and reduced expression of the p16INK4A and p21WAF1 ...
... telomerase activity. Finally, the distinct contribution of CD28 to telomerase ... telomere shortening in the replicative senescence ''program'' in T cells ... length stabilization and reduced expression of the p16INK4A and p21WAF1 ...
Página 38
... telomere length of the CD28À population was significantly shorter than that of the CD28þ population from the same donor. In fact, the mean telomere length of the CD8þCD28À T cells from persons infected with HIV (mean age 43 years) was ...
... telomere length of the CD28À population was significantly shorter than that of the CD28þ population from the same donor. In fact, the mean telomere length of the CD8þCD28À T cells from persons infected with HIV (mean age 43 years) was ...
Página 40
... telomere shortening, may be involved in other age-related diseases as well. The etiology of Alzheimer's disease (AD) is not known, but our recent studies suggest a possible involvement of T cells. We observed that the telomere length of ...
... telomere shortening, may be involved in other age-related diseases as well. The etiology of Alzheimer's disease (AD) is not known, but our recent studies suggest a possible involvement of T cells. We observed that the telomere length of ...
Página 41
... telomerase in HIV-specific CD8þ T cells:enhanced anti-viral functions accompany the increased proliferative potential and telomere length stabilization. Journal of Immunology 173, 6303–6311. Dagarag, M.D., Ng, H., Lubong, R., Effros ...
... telomerase in HIV-specific CD8þ T cells:enhanced anti-viral functions accompany the increased proliferative potential and telomere length stabilization. Journal of Immunology 173, 6303–6311. Dagarag, M.D., Ng, H., Lubong, R., Effros ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish