Handbook of Models for Human AgingP. Michael Conn Elsevier, 28/04/2011 - 1075 páginas The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues.
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Página 96
... tissues, cell lines, and animals of particular use in aging-related research, as well as a list of articles that ... tissue to researchers in the field. The site also describes its rodent resources, human biospecimens, Aging Cell ...
... tissues, cell lines, and animals of particular use in aging-related research, as well as a list of articles that ... tissue to researchers in the field. The site also describes its rodent resources, human biospecimens, Aging Cell ...
Página 100
... tissue of different origin are labeled with two distinct fluorescent dyes, such as 1-(5carboxypentyl)-10-propylindocarbocyanine halide (Cy3) N-hydroxy-succinimidyl ester and 1-(5-carboxypentyl)10-methylindodi-carbocyanine halide (Cy5) N ...
... tissue of different origin are labeled with two distinct fluorescent dyes, such as 1-(5carboxypentyl)-10-propylindocarbocyanine halide (Cy3) N-hydroxy-succinimidyl ester and 1-(5-carboxypentyl)10-methylindodi-carbocyanine halide (Cy5) N ...
Página 101
... tissue microarray (TMA). This can now be produced with good accuracy, permitting the rapid screening of a large number of human tissue sections for individual proteins (Uhlen and Ponten, 2005). Protein. Expression. Profiling. The relative ...
... tissue microarray (TMA). This can now be produced with good accuracy, permitting the rapid screening of a large number of human tissue sections for individual proteins (Uhlen and Ponten, 2005). Protein. Expression. Profiling. The relative ...
Página 102
... tissue (Dierick et al., 2002a; Gromov et al., 2002; Benvenuti et al., 2002a; 2002b) and the effect of environmental stresses (Dierick et al., 2002b; 2002c). Chang et al. have characterized the reproducibility and sensitivity of ...
... tissue (Dierick et al., 2002a; Gromov et al., 2002; Benvenuti et al., 2002a; 2002b) and the effect of environmental stresses (Dierick et al., 2002b; 2002c). Chang et al. have characterized the reproducibility and sensitivity of ...
Página 104
... tissue. However, when skeletal muscle proteins were resolved by solution isoelectric focusing/SDS-PAGE instead of ... tissue homogenates but cannot be performed in vivo. S-glutathiolation in vivo would need to be characterized by direct ...
... tissue. However, when skeletal muscle proteins were resolved by solution isoelectric focusing/SDS-PAGE instead of ... tissue homogenates but cannot be performed in vivo. S-glutathiolation in vivo would need to be characterized by direct ...
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adult age-related aged rats aging process aging research Alzheimer’s disease amyloid analysis animal models apoptosis Austad bats behavioral Biol biology brain caloric restriction cancer cellular changes chromosome cognitive colony compared correlation cortex culture decline decrease dogs Drosophila melanogaster dwarf mice effects elegans embryos factors females Figure flies function Gavrilov gene expression genetic genome Gerontol glucose GnRH Gompertz growth hippocampal honeybee hormone human aging immune impaired increase individual infection insulin laboratory levels lifespan long-lived longevity mammalian mammals mechanisms metabolic methods microarray mitochondrial molecular mortality mouse mtDNA mutations neurons normal oocytes organisms oxidative damage oxidative stress pathway phenotype physiological place cells population potential primates protein proteomic ratti receptor regulation replicative reproductive response rhesus monkeys rodents role senescence Sir2 span spatial species strains studies telomerase telomerase activity telomere telomere length tion tissue transgenic yeast zebrafish