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which manifests all the characteristics of life. The characteristics and unity of life cannot be limited to any one particular spot in a highly developed organism (for example, to the brain of man), but are to be found only in the definite, constantly recurring structure, which every individual element displays. Hence it follows that the structural composition of a body of considerable size, a so-called individual, always represents a kind of social arrangement of parts, an arrangement of a social kind, in which a number of individual existences are mutually dependent, but in such a way, that every element has its own special action, and, even though it derive its stimulus to activity from other parts, yet alone effects the actual performance of its duties. I have therefore considered it necessary, and I believe you will derive benefit from the conception, to portion out the body into cell-territories (Zellenterritorien). I say territories, because we find in the organization of animals a peculiarity which in vegetables is scarcely at all to be witnessed, namely, the development of large masses of so-called intercellular substance. Whilst vegetable cells are usually in immediate contact with one another by their

Fig. 6.

[graphic]

Fig. G. Cartilage from the epiphysis of the lower end of the humerus of a child. The object was treated first with chromate of potash, and then with acetic acid. In the homogeneous mass (intercellular substance) are seen, at a, cartilage-cavities (Knorpelhoblen) with walls still thin (capsules), from which the cartilage-cells, provided with a nucleus and nucleolus, are separated by a distinct limiting membrane, b. Capsules (cavities) with two cells, produced by the division of previously simple ones. c. Division of the capsules following the division of the cells. d. Separation of the divided capsules by the deposition between them of intercellular substance—Growth of cartilage.

CELL-TERRITORIES AND INTERCELLULAR SUBSTANCE. 15

external secreted layers, although in such a manner that the old boundaries can still always be distinguished, we find in animal tissues that this species of arrangement is the more rare one. In the often very abundant mass of matter which lies between the cells {intermediate, intercellular substance), we are seldom able to perceive at a glance, how far a given part of it belongs to one or another cell; it presents the aspect of a homogeneous intermediate substance.

According to Schwann, the intercellular substance was the cytoblastema, destined for the development of new cells. This I do not consider to be correct, but, on the contrary, I have, by means of a series of pathological observations, arrived at the conclusion that the intercellular substance is dependent in a certain definite manner upon the cells, and that it is necessary to draw boundaries in it also, so that certain districts belong to one cell, and certain others to another. You will see how sharply these boundaries are defined by pathological processes (Fig. 129), and how direct evidence is afforded, that any given district of intercellular substance is ruled over by the cell, which lies in the middle of it and exercises influence upon the neighbouring parts.

It must now be evident to you, I think, what I understand by the territories of cells. But there are simple tissues which are composed entirely of cells, cell lying close to cell. In these there can be no difficulty with regard to the boundaries of the individual cells, yet it is necessary that I should call your attention to the fact that, in this case, too, every individual cell may run its own peculiar course, may undergo its own peculiar changes, without the fate of the cell lying next it being necessarily linked with its own. In other tissues, on the contrary, in which we find intermediate substance, every cell, in addition to its own contents, has the superintendence of a certain quantity of matter external to it, and this shares in its changes, nay, is frequently affected even earlier than the interior of the cell, which is rendered more secure by its situation than the external intercellular matter. Finally, there is a third series of tissues, in which the elements are more intimately connected with one another. A stellate cell, for example, may anastomose with a similar one, and in this way a reticular arrangement may be produced, similar to that which we see in capillary vessels and other analogous structures. In this case it might be supposed that the whole series was ruled by something which lay who knows how far off; but upon more accurate investigation, it turns out that even in this chainwork of cells a certain independence of the individual members prevails, and that this independence evinces itself by single cells undergoing, in consequence of certain external or internal influences, certain changes confined to their own limits, and not necessarily participated in by the cells immediately adjoining.

That which I have now laid before you will be sufficient to show you in what way I consider it necessary to trace pathological facts to their origin in known histological elements; why, for example, I am not satisfied with talking about an action of the vessels, or an action of the nerves, but why I consider it necessary to bestow attention upon the great number of minute parts which really constitute the chief mass of the substance of the body, as well as upon the vessels and nerves. It is not enough that, as has for a long time been the case, the muscles should be singled out as being the only active elements; within the great remainder, which is generally regarded as an inert mass, there is in addition an enormous number of active parts to be met with.

Amid the development which medicine has undergone up to the present time, we find the dispute between the humoral and solidistic schools of olden times still maintained. The humoral schools have generally had the greatest success, because they have offered the most con

CELLULAR PATHOLOGY. 17

venient explanation, and, in fact, the most plausible interpretation of morbid processes. We may say that nearly all successful practical, and noted hospital, physicians have had more or less humoro-pathological tendencies; aye, and these have become so popular, that it is extremely difficult for any physician to free himself from them. The solidopathological views have been rather the hobby of speculative inquirers, and have had their origin not so much in the immediate requirements of pathology, as in physiological and philosophical, and even in religious speculations. They have been forced to do violence to facts, both in anatomy and physiology, and have therefore never become very widely diffused. According to my notions the basis of both doctrines is an incomplete one; I do not say a false one, because it is really only false in its exclusiveness; it must be reduced within certain limits, and we must remember that, besides vessels and blood, besides nerves and nervous centres, other things exist, which are not a mere theatre (Substrat) for the action of the nerves and blood, upon which these play their pranks.

Now, if it be demanded of medical men that they give their earnest consideration to these things also; if, on the other hand, it be required that, even among those who maintain the humoral and neuro-pathological doctrines, attention at last be paid to the fact, that the blood is composed of many single, independent parts, and that the nervous system is made up of many active individual constituents —this is, indeed, a requirement which at the first glance certainly offers several difficulties. But if you will call to mind that for years, not only in lectures, but also at the bedside, the activity of the capillaries was talked about—an activity which no one has ever seen, and which has only been assumed to exist in compliance with certain theories —you will not find it unreasonable, that things which are really to be seen, nay are, not unfrequently, after practice, accessible even to the unaided eye, should likewise be admitted into the sphere of medical knowledge and thought. Nerves have not only been talked about where they had never been demonstrated; their existence has been simply assumed, even in parts in which, after the most careful investigations, no trace of them could be discovered, and activity has been attributed to them in parts where they absolutely do not penetrate. It is therefore certainly not unreasonable to demand, that the greater part of the bodybe no longer entirely ignored; and if no longer ignored, that we no longer content ourselves with merely regarding the nerves as so many wholes, as a simple, indivisible apparatus, or the blood as a merely fluid material, but that we also recognise the presence within the blood and within the nervous system of the enormous mass of minute centres of action.

In conclusion, I have still some preparations to explain,

and will begin with a very common object (Fig. 7). It has

been taken from the tuber of a potato, at a spot where

you can view in its perfection the strac

7" ture of a vegetable cell, where the tuber,

namely, is beginning to put forth a new

shoot, and there is, consequently, a

probability of young cells being found,

at least, if we suppose that all growth

consists in the development of new cells.

In the interior of the tuber all the cells

are, as is well known, stuffed full with

granules of starch; in the young shoot, on the other hand,

Fig. 7. From the cortical layer of a tuber of solarium tuberosum, after treatment with iodine and sulphuric acid. a. Flat cortical cells, surrounded by their capsule (cell-wall, membrane), b. Larger, four-sided cells of the same kind from the cambium; the real cell (primordial utricle), shrunken and wrinkled, within the capsule, c. Cells with starch-granules lying within the primordial utricle.

[graphic]
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