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LECTURE XIV.-ACTIVITY AND IRRITABILITY OF CEL-

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Difference between formation and transformation. Fresh and growing,

in opposition to macerated, bone. Nature of medullary tissue.-Growth

in length of tubular [long] bones; proliferation of cartilage. Formation

of marrow as a transformation of tissue; red and yellow, normal and

inflammatory marrow. Osseous tissue, calcified cartilage, osteoid tissue.

Bone-territories: caries, degenerative ostitis. Granulation of bone.

Suppuration of bone. Maturation of pus. Ossification of marrow. -

Growth of long bones in thickness; structure and proliferation of the

periosteum.-Granulations as analogous to the medulla of bones, and as

the starting-point of all heteroplastic development.

LECTURE XIX.-PATHOLOGICAL, AND ESPECIALLY HETE-

ROLOGOUS, NEW FORMATION

Consideration of some forms of pathological formation of bone. Soft oste-

oma of the maxillæ. Rickets. Formation of callus after fracture.-

Theory of substitutive new formation in opposition to exudative.

Destructive nature of new-formations. Homology and heterology

(malignity). Ulceration. Mollities ossium. Proliferation and luxuria-

tion. Medulla of bones and pus.-Suppuration. Its two forms: super-

ficial, occurring in epithelium; and deep, in connective tissue. Eroding

suppuration (skin, mucous membrane): pus- and mucus-corpuscles in

their relations to epithelium. Ulcerative suppuration. Solvent pro-

perties of pus.-Connection of destruction with pathological growth and

proliferation. Correspondence of the first stage in pus, cancer, sarcoma,

&c. Possible duration of the life of pathologically new-formed elements,

and of pathological new-formations considered as wholes (tumours).

Compound nature of the larger tuberous tumours (Geschwulstknoten),

and miliary character of the real foci (Heerde). Conditions of growth

and recurrence: contagiousness of new-formations and import of the anas-

tomoses of cells. Cellular pathology in opposition to the humoral and

neuristic. General infection of the body. Parasitism and autonomy of

new-formations.

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