Handbook of models for human aging
This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. *Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations
Handbook
1 online resource (xxi, 1075 pages) : illustrations (some color)
9780123693914, 9780080460062, 0123693918, 0080460062
162572988
I. Introduction
II. Animal Models
III. Comparative Models of Aging and Age-Related Diseases. Historical development of animal models of aging / Richard L. Sprott and Steven N. Austad
Species selection in comparative studies of aging and antiaging research / João Pedro de Magalhães
Principles of animal use for gerontological research / Richard A. Miller
from primary cultures to the aging organism: lessons from human T lymphocytes / Rita B. Effros
Models of systems failure in aging / Leonid A. Gavrilov and Natalia S. Gavrilova
Major issues in ethics of aging research / Michael D. Smith
Ethical aspects of research involving elderly persons / Paul S. Mueller and C. Christopher Hook
SAGE KE and other online sources related to aging / Evelyn Strauss and R. John Davenport
Proteomics in aging research / Christian Schöneich
Application of high-throughput technologies to aging-related research / Matt Kaeberlein
Models of Alzheimer's disease / Harry LeVine III and Lary C. Walker
Age-related hippocampal dysfunction: early Alzheimer's disease vs. normal aging / Scott A. Small
Epidemiology in aging research / Hermann Brenner and Volker Arndt. Statistical issues for longevity studies in animal models / Chenxi Wang [and others]
Models for the study of infection in populations / John R. Williams
Estimation of the rate of production of oxygen radicals by mitochondria / Alberto Sanz and Gustavo Barja
Telomeres and aging in the yeast model system / Kurt W. Runge
Longevity and aging in budding yeast / Matt Kaeberlein
From yeast Methuselah genes to evolutionary medicine / Paolo Fabrizio and Valter D. Longo
Strongyloides ratti: a nematode wth extraordinary plasticity in aging / Michael P. Gardner, David Gems, and Mark E. Viney
Insect models for the study of aging / Klaus-Günter Collatz
Drosophila models of aging / Satomi Miwa and Alan Cohen
Models of aging in honeybee workers / Gro v. Amdam and Olav Rueppell
Ants as naturally long-lived insect models for aging / Joel D. Parker and Karen M. Parker
Gene expression and the extended longevity phenotypes of Drosophila melanogaster / Robert Arking
Annual fish as a genetic model for aging / Pudur Jagadeeswaran. The use of mature zebrafish (Danio rerio) as a model for human aging and disease / Evan T. Keller, Jill M. Keller, and Gavin Gillespie
Zebrafish as aging models / Shuji Kishi
Telomeres in aging: birds / Susan E. Swanberg and Mary E. Delany
Domestic and wild bird models for the study of aging / Donna J. Holmes and Mary Ann Ottinger
A transgenic mini rat strain as a tool for studying aging and calorie restriction / Isao Shimokawa
Rat models of age-related cognitive decline / Jennifer L. Bizon and Michelle M. Nicolle
Aged rodents for biogerontology research / Nancy L. Nadon
Life extension in the dwarf mouse / Andrzej Bartke
The canine model of human brain aging: cognition, behavior, and neuropathology / P. Dwight Tapp and Christina T. Siwak
Bats as a novel model for aging research / Anja K. Brunet-Rossinni and Rocco E. Rossinni
Memory in the aging hippocampus: what can place cells tell us? / Iain A. Wilson
The rhesus macaque as a model of human aging and age-related disease / Mary Ann Ottinger [and others]. Nonhuman primates as a models for reproductive aging and human infertility / Barry D. Bavister and Carol A. Brenner
Neurobiology fo the aging brain / Carlo Bertoni-Freddari [and others]
Mitochondrial DNA and aging / Mikhail Alexeyev, Susan P. LeDoux, and Glenn L. Wilson
Models for apoptosis: from newborn to adult / Christiane Charriaut-Marlangue and Sylvain Renolleau
Age-related changes in hormones and their receptors in animal models of female reproductive senescence / Jacqueline A. Maffucci and Andrea C. Gore
Models of chaperones in aging / Jens Krøll and J.O. Nehlin
Therapeutic potential of stem cells in aging-related diseases / Shannon Whirledge, Kirk C. Lo, and Dolores J. Lamb
Nuclear transfer and cloning: preservation or expansion of proliferative lifespan? / Keith E. Latham
Human models of longevity / Thomas Perls
Computational models of mitochondrial DNA in aging / David C. Samuels
Mouse models of accelerated aging / Jan Vijg and Paul Hasty. Models, definitions, and criteria of frailty / David B. Hogan
Fertility and aging men: an introduction to the male biological clock / Peter N. Schlegel [and others]
Benign prostatic hyperplasia / Peter Celec
Murine models of infectious diseases in the aged / Kevin P. High
Studying infection in the elderly: physiopathology, clinical symptoms and causative agents of pneumonia / Jean-Paul Janssens
Diabetes and aging / Tamas Fülöp [and others]
Diabetes as a model of premature aging / Arshag D. Mooradian
Frailty as a model of aging / Jeremy d. Walston
Osteoporosis and cardiovascular disease in the elderly / Samy I. McFarlane, John Nicasio, and Ranganath Muniyappa
Depression in older patients / Kiran Rabheru
The aging human lung: age-associated changes in structure and function / Keith C. Meyer
Iceland as a model for human aging / Adalsteinn Gudmundsson and Pálmi V. Jónsson. Behavior and personality in the study of successful aging / Judith Corr and Loraine Tarou
Andropause / Rabih Hijazi and Glenn R. Cunningham
Aging and the perceptual organization of sounds: a change of scene? / Claude Alain, Benjamin J. Dyson, and Joel S. Snyder
Models of immune function in aging / Christopher a. Jolly and Zhun Xu
Human T cell clones in long-term culture as models for the impact of chronic antigenic stress in aging / Graham Pawelec [and others]
Age-related changes in the human retina / Carlo Cavallotti and Nicola Pescosolido
Models of age-related vision problems / J. Fielding Hejtmancik, Mark Kantorow, and Takeshi Iwata
Health, functional and therapeutic implications of obesity in aging / R. Lee Kennedy and E.Y.H. Khoo
Age and joints / Klaus Bobacz and Ilse-Gerlinde Sunk
Sleep quality in the elderly / Ragnar Asplund
Atherogenesis and aging / Cam Patterson. Managing menopausal symptoms / Mary Ellen rousseau
Psychological aging: a contextual view / Hans-Werner Wahl and Frieder R. Lang
Nutrients and aging / Lawrence J. Whalley
Methods for studying hearing impairment and auditory problems of the aged / Robert D. Frisina and D. Robert Frisina
A mdoel for understanding the pathomechanics of osteoarthritis in aging / Thomas P. Andriacchi and Annegret Mündermann
Aging and cardiovascular angiogenesis models / Andrew Chin [and others]
Models for the study of stroke / Thiruma V. Arumugam and Mark P. Mattson
Werner syndrome as a model of human agiing / Raymond J. Monnat, Jr
Models of sarcopenia / Alfred L. Fisher
Aging of human skin / Paolo U. Giacomoni
Models of hypertension in aging / Jane F. Reckelhoff [and others]
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